Beclometasone dipropionate

SKU: orb1309679

Description

Beclometasone dipropionate is a synthetic glucocorticoid ester with potent anti-inflammatory and immunomodulatory effects. It acts by binding to nuclear receptors to alter gene expression and suppress pro-inflammatory cytokines. This compound is widely used in research models of asthma, allergic rhinitis, and other inflammatory conditions, both in vitro and in vivo.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 5534-09-8
• MW: 521.04
• Purity: 99.44% (May vary between batches)
• Formula: C₂₈H₃₇ClO₇
• SMILES: [H][C@@]12C[C@H](C)[C@](OC(=O)CC)(C(=O)COC(=O)CC)[C@@]1(C)C[C@H](O)C1(Cl)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
• Target: Reactive Oxygen Species,ROS,Glucocorticoid Receptor,NO Synthase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.84 mM);Ethanol:18 mg/mL (34.55 mM);DMSO:55 mg/mL (105.56 mM)

Bioactivity

• In Vitro:
  Beclomethasone dipropionate (BDP) is an anti-inflammatory corticosteroid available for the treatment of asthma and allergic rhinitis (AR). BDP is previously developed as aqueous nasal formulations for the treatment of AR. BDP is also available in dry nasal aerosol formulations as chlorofluoro carbon (CFC) metered-dose inhaler nasal sprays, but CFC-containing formulations have been withdrawn from the market and currently are not available.BDP hydrofluoroalkane (HFA) inhalation aerosol currently is available for patient use and indicated for the maintenance treatment of asthma as prophylactic therapy in patients 5 years of age and older.BDP HFA nasal aerosol, an intranasal aerosol formulation, has been developed recently for the treatment of AR.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

asthma, Beconase, Beclometasone, Beclometasone dipropionate, Beclometasone Dipropionate, Beclomethasone, Beclomethasone Dipropionate, Beclomethasone dipropionate, Beclovent, 16HBE cells, Inhibitor, iNOS, GlucocorticoidReceptor, Glucocorticoid Receptor, inflammation, inhibit, Vancenase, STAT-1

Compound Identifiers

PubChem CID

146777