BDW568

• Catalog Number: orb1979964
• Category: Small Molecules
• Description: BDW568, a prodrug of BDW-OH, serves as a stimulator of interferon genes (STING) agonist. This compound effectively induces STING transcriptional activity, evidenced by a reporter assay in THP-1 cells, with an EC50 value of 7.6 µM. Furthermore, at a concentration of 50 µM, BDW568 prompts phosphorylation of TANK-binding kinase 1 (TBK1) and IFN regulatory factor 3 (IRF3) within THP-1 cells, showcasing its biochemical activity in cellular signaling pathways.
• Purity: 98.00%
• MW: 308.38
• Biological Activity: BDW568, a prodrug of BDW-OH, serves as a stimulator of interferon genes (STING) agonist. This compound effectively induces STING transcriptional activity, evidenced by a reporter assay in THP-1 cells, with an EC50 value of 7.6 µM. Furthermore, at a concentration of 50 µM, BDW568 prompts phosphorylation of TANK-binding kinase 1 (TBK1) and IFN regulatory factor 3 (IRF3) within THP-1 cells, showcasing its biochemical activity in cellular signaling pathways.
• CAS Number: 335401-44-0
• Formula: C₁₂H₁₂N₄O₂S₂
• SMILES: O=C(OC)CSC1=NN=C2N1C=NC3=C2C(C)=C(C)S3
• Storage: -20°C
• Note: For research use only