BDP9066

SKU: orb1707580

Description

BDP9066 is a potent, selective MRCK inhibitor targeting both MRCKα and MRCKβ isoforms. It has demonstrated utility in research exploring cell motility and cytoskeletal dynamics, with studies indicating potential for skin cancer intervention in preclinical models.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2226507-04-4
• MW: 348.44
• Purity: 98.62% (May vary between batches)
• Formula: C₂₀H₂₄N₆
• SMILES: C1CC[C@@]2(CCCN(C2)c2cc[nH]c3ncc(-c4ccncn4)c23)NC1
• Target: ROCK,Ras
• Solubility: DMSO:8 mg/mL (22.96 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.87 mM)

Bioactivity

• Target IC50:
  MRCKα/β:（ki）0.0136 nM/0.0233 nM|MRCKα/β:0.0136 nM/0.0233 nM ( Ki)|MRCKβ (SCC12 cells):64 nM
• In Vivo:
  As an effective and selective MRCK inhibitor, BDP9066, in a two-stage chemical carcinogenesis model of mouse squamous cell carcinoma, reduced MRCKα S1003 phosphorylation and the growth of skin tumors with local treatment.
  Read more...
• In Vitro:
  Among over 750 human cancer cell lines tested, BDP9066 consistently exhibited anti-proliferative activity in hematologic cancer cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BDP 9066, BDP9066, BDP-9066, MRCK, MRCKα/β, MRCKβ

Compound Identifiers

PubChem CID

132275018