BCR-ABL-IN-4

SKU: orb1686108

Description

BCR-ABL-IN-4 is a potent small molecule inhibitor targeting BCR-ABL, demonstrating significant anti-proliferative activity in vitro. It effectively inhibits K562 cells (IC50: 0.67 nM) and the resistant BCR-ABL T315I mutant in Ba/F3 cells (IC50: 16 nM), making it a valuable tool for chronic myeloid leukemia (CML) and drug resistance research.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2669790-59-2
• MW: 555.96
• Formula: C₂₇H₂₄ClF₂N₅O₄
• SMILES: C(NC1=CC=C(OC(Cl)(F)F)C=C1)(=O)C2=CC(=C(N=C2)N3C[C@H](O)CC3)C=4C=C5C(=NC4)CN(C5=O)C6CC6
• Target: Others,Bcr-Abl

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

163322002