BCR-ABL-IN-13

SKU: orb3209959

Description

BCR-ABL-IN-13 is a dual c-Src and Abl inhibitor, with a Ki value of 0.55 μM against c-Src, 0.10 μM against wild-type Abl, and 0.40 μM against the AblT315I mutant. BCR-ABL-IN-13 exerts competitive/mixed-type inhibitory effects on wild-type Abl, and non-competitive inhibitory effects on the drug-resistant AblT315I mutant. BCR-ABL-IN-13 is used in chronic myeloid leukemia research models to study kinase inhibition profiles, resistance-associated Abl mutations, and signaling pathway modulation in oncogenic tyrosine kinase systems.

Key Properties

• CAS Number: 607702-99-8
• MW: 363.41
• Purity: 99.92% (May vary between batches)
• Formula: C₁₆H₁₁F₂N₃OS₂
• SMILES: O=C(NC1=NN=C(S1)SCC2=CC=C(F)C=C2)C3=CC=C(F)C=C3
• Target: Src,Bcr-Abl

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Src,Bcr-Abl