BCL-xL/BCL-2 ligand 1

SKU: orb2566865

Description

Compound 72-1 (BCL-xL/BCL-2 ligand 1) is a small molecule ligand for BCL-xL and BCL-2 proteins. It is utilized in PROTAC development by tethering to E3 ligases via a linker, enabling targeted protein degradation studies in cancer research, applicable in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2941091-91-2
• MW: 1000.61
• Formula: C₄₈H₅₃ClF₃N₅O₇S₃
• SMILES: C(C1=C(CC[C@](C=O)(C)C1)C2=CC=C(Cl)C=C2)N3CCN(CC3)C4=CC=C(C(NS(=O)(=O)C5=CC(S(C(F)(F)F)(=O)=O)=C(N[C@H](CCN6[C@@]7(C[C@](C6)(OC7)[H])[H])CSC8=CC=CC=C8)C=C5)=O)C=C4
• Target: Ligands for E3 Ligase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172395853