BCL-XL-IN-3

SKU: orb2814311

Description

BCL-XL-IN-3 (Compound 11) is a potent BCL-XL inhibitor (Ki <0.01 nM) with EC50 values of 77.8 nM and 0.07 nM in intact and permeabilized Molt-4 cells, respectively. It serves as a payload for antibody-drug conjugates like Clezutoclax in cancer research, enabling targeted apoptosis induction in vitro.

Research Area

Cell Biology

Key Properties

• CAS Number: 1949840-87-2
• MW: 834.04
• Formula: C₄₆H₅₅N₇O₆S
• SMILES: C(C12CC3(OCCNCC[C@@H](CO)O)CC(C)(C1)CC(C)(C2)C3)N4C(C)=C(C=N4)C5=C(C(O)=O)N=C(C=C5)N6CC7=C(C(NC8=NC=9C(S8)=CC=CC9)=O)C=CC=C7CC6
• Target: Bcl-2 Family

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

122700649