Bcl-xL antagonist 2

SKU: orb1303646

Description

Bcl-xL antagonist 2

Research Area

Cell Biology, Pharmacology & Drug Discovery; Cell Biology

Key Properties

• CAS Number: 1235032-75-3
• MW: 436.51
• Purity: 99.81% (May vary between batches)
• Formula: C₂₁H₁₆N₄O₃S₂
• SMILES: OC(=O)c1csc(n1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1
• Target: Apoptosis,Bcl-2 Family
• Solubility: 10% DMSO+90% Corn Oil:5 mg/mL (11.45 mM);DMSO:50 mg/mL (114.54 mM)

Bioactivity

• Target IC50:
  BCL-XL:0.091 μM
• In Vivo:
  Bcl-xL antagonist 2 (1 mg/kg;i.v.) exhibits good PK profile with CL, Vss, t1/2 and F of 0.47 mL/min/kg, 0.16 L/kg, 6.0 h and 16% in rats.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BclxL antagonist 2, Bcl-xL antagonist 2, Bcl-xL, Bcl xL antagonist 2

Compound Identifiers

PubChem CID

46836567