Bcl-2-IN-5

SKU: orb1983055

Description

Bcl-2-IN-5 is a highly potent small molecule BCL-2 inhibitor, showing sub-nanomolar IC50 values against wild-type and mutant (D103Y, G101V) proteins. It also demonstrates potent anti-proliferative activity in Bcl-2-G101V mutant RS4;11 cell lines. This inhibitor is a valuable research tool for studying apoptosis and resistance mechanisms in hematological cancers.

Research Area

Cell Biology

Key Properties

• CAS Number: 2728752-20-1
• MW: 1015.2
• Formula: C₅₅H₆₃FN₈O₈S
• SMILES: COc1ccc(CN2CCN(C3CC4(C3)CN(C4)c3ccc(C(=O)NS(=O)(=O)c4ccc(NC[C@H]5CC[C@](C)(O)CC5)c(c4)N(=O)=O)c(Oc4cnc5[nH]cc(F)c5c4)c3)[C@@H](C2)c2ccccc2C(C)C)cc1
• Target: Others,Bcl-2 Family

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

163322038