BCI hydrochloride

SKU: orb1710302

Description

BCI hydrochloride

Research Area

Metabolism Research

Key Properties

• CAS Number: 95130-23-7
• MW: 353.89
• Purity: 99.95% (May vary between batches)
• Formula: C₂₂H₂₄ClNO
• SMILES: Cl.O=C1C=2C=CC=CC2C(NC3CCCCC3)C1=CC=4C=CC=CC4
• Target: Phosphatase
• Solubility: DMSO:10 mg/mL (28.26 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.83 mM)

Bioactivity

• In Vitro:
  BCI hydrochloride (100 ng/mL; 24 hr) was able to down-regulate DUSP6 expression in RAW264.7 macrophages.BCI hydrochloride (0-1 nM; 24 hr) inhibited DUSP6 expression, as well as IL-1β and IL-6 production in lipopolysaccharide (LPS)-activated macrophages.BCI hydrochloride (0-4 nM; 24 hr), in turn reduced reactive oxygen species (ROS) production and activated the Nrf2 pathway in LPS-activated macrophages.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DUSP6, (E)-BCI hydrochloride

Compound Identifiers

PubChem CID

69670470