BCH001

SKU: orb1298747

Description

BCH001

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 384859-58-9
• MW: 420.34
• Purity: 99.15% (May vary between batches)
• Formula: C₂₀H₁₅F₃N₂O₅
• SMILES: CCOC(=O)c1cnc2ccc(OC(F)(F)F)cc2c1Nc1ccccc1C(O)=O
• Target: DNA/RNA Synthesis
• Solubility: DMSO:84 mg/mL (199.84 mM)

Bioactivity

• In Vivo:
  BCH001, a specific PAPD5 inhibitor that restored telomerase activity and telomere length in DC patient induced pluripotent stem cells. When human blood stem cells engineered to carry DC-causing PARN mutations were xenotransplanted into immunodeficient mice, oral treatment with a repurposed PAPD5 inhibitor, the dihydroquinolizinone RG7834, rescued TERC 3' end maturation and telomere length.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BCH001, BCH-001, BCH 001, DNASynthesis, DNA Synthesis, DNA/RNA Synthesis, dyskeratosis, congenita, inhibit, iPSC, PARN, PAPD5, oligo-adenylation, pluripotent, ncRNA, Inhibitor, polynucleotide, polymerases, rPAPD5, RNA Synthesis, RNASynthesis, telomere, telomerase, TERC, stem

Compound Identifiers

PubChem CID

1043578