BC1618

SKU: orb1298516

Description

BC1618 is an orally bioavailable small molecule inhibitor of Fbxo48 that activates AMPK signaling. This compound induces mitochondrial fission and autophagy, leading to improved hepatic insulin sensitivity in research models, making it a useful tool for studying metabolism and metabolic diseases.

Research Area

Cell Biology, Epigenetics & Chromatin, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 2222094-18-8
• MW: 415.45
• Purity: 99.95% (May vary between batches)
• Formula: C₂₄H₂₄F₃NO₂
• SMILES: OC(COc1ccc(cc1)C(F)(F)F)CN(Cc1ccccc1)Cc1ccccc1
• Target: Mitophagy,E1/E2/E3 Enzyme,AMPK
• Solubility: DMSO:100 mg/mL (240.7 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (7.94 mM)

Bioactivity

• In Vivo:
  BC1618, whose potency in stimulating Ampk-dependent signaling greatly exceeds 5-aminoimidazole-4-carboxamide-1-β-ribofuranoside (AICAR) or metformin. This compound increases the biological activity of Ampk not by stimulating the activation of Ampk, but rather by preventing activated pAmpkα from Fbxo48-mediated degradation. Consistenting with augmenting Ampk activity, BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity in high-fat-diet-induced obese mice.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

E1 activating enzyme, E3 Enzyme, E2Enzyme, E2 Enzyme, E2 conjugating enzyme, E1Enzyme, E1 Enzyme, E1/E2/E3 Enzyme, E3 ligating enzyme, E3Enzyme, 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-, AMPK, AMP-activated protein kinase, BC1618, BC-1618, BC 1618, LPS, Inhibitor, inhibit, mTORC, mitochondrial, Mitochondrial Autophagy, Mitophagy, metformin, pAmpk, insulin, Fbxo48, fission, pS6, Ubiquitin activating enzyme, Ubiquitin ligase, Ubiquitin conjugating enzyme

Compound Identifiers

PubChem CID

134417552