BC-1382

SKU: orb1298829

Description

BC-1382 is a potent and selective small molecule inhibitor of the HECTD2 E3 ubiquitin ligase, disrupting its interaction with PIAS1 with an IC50 of 5 nM. This tool compound enables the study of HECTD2-mediated ubiquitination in cellular and biochemical assays, facilitating research into related signaling pathways and protein homeostasis.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 1013753-99-5
• MW: 459.56
• Purity: 99.94% (May vary between batches)
• Formula: C₂₃H₂₉N₃O₅S
• SMILES: COc1ccccc1CNC(=O)C(C)NC(=O)C1CCN(CC1)S(=O)(=O)c1ccccc1
• Target: E1/E2/E3 Enzyme
• Solubility: DMSO:55 mg/mL (119.68 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.35 mM)

Bioactivity

• In Vitro:
  BC-1382, that targeted HECTD2 and attenuated lipopolysaccharide (LPS)- and Pseudomonas aeruginosa-induced lung inflammation.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ubiquitin E3 ligase HECTD2, Ubiquitin conjugating enzyme, Ubiquitin ligase, Ubiquitin activating enzyme, Ubiquitin, BC1382, BC-1382, BC 1382, E1Enzyme, E1/E2/E3 Enzyme, E2 conjugating enzyme, E1 activating enzyme, E1 Enzyme, E2 Enzyme, E2Enzyme, E3 Enzyme, E3Enzyme, E3 ligating enzyme, lung, Inhibitor, ligase, inhibit, inflammation, HECTD2, HECTD2/PIAS1, interaction,Anti-inflammatory

Compound Identifiers

PubChem CID

73401464