BBT

SKU: orb2278896

Description

BBT exhibits anti-hyperglycemic properties by protecting pancreatic β-cells from cytokine- and streptozotocin-induced apoptosis via cAMP/PKA and L-type Ca2+ channel/CaMKII pathways. This small molecule is utilized in diabetes research to investigate β-cell survival and function restoration in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 445000-45-3
• MW: 386.26
• Purity: 99.02% (May vary between batches)
• Formula: C₁₈H₁₂BrNO₂S
• SMILES: O=C(NC=1C=CC=CC1C(=O)C=2C=CC=CC2)C=3SC(Br)=CC3
• Target: Calcium Channel
• Solubility: DMSO:100 mg/mL (258.89 mM)

Bioactivity

• In Vivo:
  BBT (50 mg/kg/day intravenously for 4 weeks) improved glucose homeostasis in STZ/ HFD-induced type 2 diabetes mice.
• In Vitro:
  BBT stimulates insulin secretion in a glucose-dependent manner. BBT effectively reversed β cell death induced by treatment with STZ (0.4 mM) or cytokines (10 ng/ml TNF-α and 5 ng/ml IL1B) in a dose-dependent manner. BBT can reverse STZ or cytokine-induced GSIS defects.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CalciumChannel, Calcium Channel

Compound Identifiers

PubChem CID

1008832