BB-78485

SKU: orb1701099

Description

BB-78485 is a potent LpxC inhibitor with an IC50 of 160 nM, exhibiting antibacterial activity against Gram-negative bacteria. It serves as a valuable research tool for studying bacterial lipid A biosynthesis in both in vitro enzymatic assays and in vivo infection models.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 207732-11-4
• MW: 420.48
• Purity: >99.99% (May vary between batches)
• Formula: C₂₃H₂₀N₂O₄S
• SMILES: S(N[C@H](CC1=CC2=C(C=C1)C=CC=C2)C(NO)=O)(=O)(=O)C3=CC4=C(C=C3)C=CC=C4
• Target: Others,Antibacterial

Bioactivity

• Target IC50:
  LpxC:160 nM
• In Vitro:
  BB-78485 can inhibit LpxC with an IC50 value of 160 nM.BB-78485 is effective against D21 and D22 (lpxC101), with MIC values of 2 μg/mL and 0.016 μg/mL, respectively.The MIC values of BB-78485 against Enterobacteriaceae, Serratia marcescens, Morganella morganii, Moraxella catarrhalis, Haemophilus influenzae, and Burkholderia cepacia range from 1 μg/mL to 32 μg/mL.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BB 78485, BB78485, BB-78485, LpxC

Compound Identifiers

PubChem CID

9823454