Bazedoxifene hydrochloride

SKU: orb1686000

Description

Bazedoxifene hydrochloride

Research Area

Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 198480-56-7
• MW: 507.06
• Purity: 98.74%
• Formula: C₃₀H₃₅ClN₂O₃
• SMILES: Cl.OC=1C=CC(=CC1)C2=C(C3=CC(O)=CC=C3N2CC4=CC=C(OCCN5CCCCCC5)C=C4)C
• Target: Estrogen/progestogen Receptor,Interleukin,Estrogen Receptor/ERR,IL Receptor
• Solubility: H2O:<1 mg/mL;DMSO:93 mg/mL (183.41 mM);Ethanol:<1 mg/mL

Bioactivity

• Target IC50:
  ERβ (rat):99 nM|ERα: 23 nM|ERα:26 nM|ERβ:89 nM
• In Vivo:
  In 6-week-old f Male athymic nude mice, Bazedoxifene hydrochloride ( 5 mg/kg ; oral gavage, daily, for 18 days ) was used to Suppressed pancreatic cancer xenograft tumor growth and induced apoptosis in tumor cell.
• In Vitro:
  In AsPC-1 cells, Bazedoxifene hydrochloride (at concentration of 10 μM and 20 μM; treated for 2 hours) is able to inhibit STAT3 phosphorylation induced by IL-6, IL-11, or OSM Each at 50 ng/mL.
• Cell Research:
  Fo the proliferation assay, cells are plated at 20,000 cells/well in a 24-well plate in DMEM/F12 (50:50) (phenol red-free) with 10% charcoal/dextran-treated FBS and 1 × GlutaMAX-1. After overnight incubation the medium is aspirated and treatments in DMEM/F12 (50:50) (phenol red-free) with 2% charcoal/dextran-treated FBS and 1 × GlutaMAX-1 are added to the wells. Each plate has a Vehicle (baseline proliferation) and treatments. Treatments included 10 pM 17β-estradiol determined to b the EC80 for 17β-estradiol and 17β-estradiol in combination with Six concentration of BZA. Treatments from d 1 are renewed on d 3 and d 6 by aspirating medium from wells and replacing with fresh medium and treatments. On d 7, cells are detached fro the plate using trypsin-EDTA and counted using a Multisizer II.(Only for Reference)

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Bazedoxifene, Bazedoxifene HCl, interactions, IL Receptor, estrogen, Estrogen Receptor, GP130, EstrogenReceptor, Estrogen Receptor/ERR, ERR, ERα, ERβ, ILReceptor, IL-6, IL-6/GP130, modulator, receptor, selective, WAY 140424 hydrochloride, SERM, STAT3, progestogenReceptor, progestogen Receptor, protein-protein, TSE 424, TSE 424 hydrochloride, TSE424, TSE-424, TSE424 hydrochloride, TSE-424 hydrochloride

Compound Identifiers

PubChem CID

9936012