BAY-985

SKU: orb1309942

Description

BAY-985

Research Area

Signal Transduction

Key Properties

• CAS Number: 2409479-29-2
• MW: 553.58
• Purity: 99.30% (May vary between batches)
• Formula: C₂₇H₃₀F₃N₉O
• SMILES: C[C@@H](N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N(C)C)c1
• Target: IκB/IKK
• Solubility: DMSO:50 mg/mL (90.32 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.61 mM)

Bioactivity

• Target IC50:
  TBK1:2 nM (low ATP)|TBK1:30 nM (high ATP)|IKKε:2 nM
• In Vivo:
  BAY-985 (200 mg/kg; p.o.; b.i.d.; 111 days) results in weak antitumor efficacy. BAY-985 shows high clearance (CLb= 4.0 L/h/kg, ca. 95% hepatic extraction), large volume of distribution at steady state (Vss=2.9 L/kg) and a short terminal half-life (t1/2=0.79 h).
  Read more...
• In Vitro:
  BAY-985 inhibits FLT3, RSK4, DRAK1, and ULK1 (IC50s: 123, 276, 311, and 7930 nM). BAY-985 inhibits the cellular phosphorylation of interferon regulatory factor 3 (IRF3, IC50: 74 nM). BAY-985 shows anti-proliferative activity in a few cancer cell lines (IC50s: 900 and 7260 nM for SK-MEL2 (NRAS and TP53 mutated) and ACHN (CDKN2A mutated) cells).
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TBK1, antitumor, BAY 985, BAY985, BAY-985, inhibit, IκB kinase, IκB, I kappa B kinase, Inhibitor, melanoma, IkB/IKK, IKK, IKKε, IkB

Compound Identifiers

PubChem CID

145925685