BAY 80-6946

SKU: orb1227108

Description

BAY 80-6946 (Copanlisib) is a potent and highly selective reversible PI3K inhibitor for PI3Kα/β with IC50 of 0.469 nM/3.72 nM. Phase 2.

Key Properties

• CAS Number: 1032568-63-0
• MW: 480.52
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₈N₈O₄
• SMILES: COC1=C(C=CC2=C1N=C(N3C2=NCC3)NC(=O)C4=CN=C(N=C4)N)OCCCN5CCOCC5
• Target: PI3K
• Solubility: DMSO:0.002 mg/mL (0.0 mM); Ethanol:0.01 mg/mL (0.02 mM); Water:0.002 mg/mL

Bioactivity

• In Vivo:
  Animal model: Athymic nude rats injected with KPL4 tumor cells. Dosage: 0.5 mg/kg, 1 mg/kg, 3 mg/kg or 6 mg/kg. Administration: Intravenous injection; every second day, every third day; for 60 days. Result: On day 25, tumor growth inhibition (TGI) rates of 77%, 84%, 99%, and 100% were observed at doses of 0.5, 1, 3, and 6 mg/kg, respectively. All rats remained tumor free at the termination of the study on day 73.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Copanlisib

Quick Database Links

Gene Symbol

PI3K