Bay 60-7550

SKU: orb1707589

Description

Bay 60-7550 is a potent and selective phosphodiesterase 2 (PDE2) inhibitor with a Ki of 3.8 nM. It enhances cardiac contractility in rats via PKA signaling and is utilized in research models for cognitive and memory dysfunction, supporting investigations in neuroscience and cardiovascular pharmacology.

Research Area

Metabolism Research

Key Properties

• CAS Number: 439083-90-6
• MW: 476.57
• Purity: 98.14% (May vary between batches)
• Formula: C₂₇H₃₂N₄O₄
• SMILES: COc1ccc(Cc2nc(=O)c3c(C)nc([C@@H](CCCc4ccccc4)[C@@H](C)O)n3[nH]2)cc1OC
• Target: PDE
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.2 mM);DMSO:30 mg/mL (62.95 mM)

Bioactivity

• Target IC50:
  PDE2:3.8±0.2 nM （Ki）
• In Vivo:
  Administration of the PDE2 inhibitors Bay 60-7550 (0.5, 1, and 3 mg/kg) or ND7001 (1 mg/kg), or the NO donor detanonoate (0.5 mg/kg), antagonized the anxiety-like behavior induced by restraint stress in mice .
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• In Vitro:
  The anti-proliferative effect of BAY 60-7550 (1 μM) is pronounced, with a significant decrease in proliferation observed in PASMCs from IPAH patients compared to untreated control cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PDE2, BAY607550, BAY-607550, Bay 60 7550, BAY 607550, Bay 60-7550

Compound Identifiers

PubChem CID

135564787