BAY-524

SKU: orb1308582

Description

BAY-524 is a potent and selective small molecule inhibitor of the mitotic kinase Bub1, exhibiting an IC50 of 450 nM against the human enzyme with 2 mM ATP. This compound is a valuable research tool for studying chromosome segregation, spindle assembly checkpoint function, and mitotic progression in cellular and biochemical assays.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 1445830-39-6
• MW: 482.48
• Purity: 99.81% (May vary between batches)
• Formula: C₂₄H₂₄F₂N₆O₃
• SMILES: CCOc1cc(F)c(Cn2nc(c(C)c2OC)-c2ncc(OC)c(Nc3ccncc3)n2)c(F)c1
• Target: Others,Serine/threonin kinase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.36 mM);DMSO:150 mg/mL (310.89 mM)

Bioactivity

• Target IC50:
  Bub1, 2 mM ATP (human):450 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

recombinant catalytic domain, Shugoshin proteins (Sgo1and Sgo2), inhibit, Inhibitor, human Bub1, 2 mM ATP, anti-cancer, BAY 524, BAY524, BAY-524, BUB1 kinase, Bub1 kinase

Compound Identifiers

PubChem CID

71611179