BAY 41-2272

SKU: orb1300478

Description

BAY 41-2272 is a soluble guanylate cyclase (sGC) stimulator that activates the enzyme independently of nitric oxide. It is utilized in cardiovascular and pulmonary hypertension research, demonstrating efficacy in both in vitro assays and in vivo animal models to study cGMP-mediated signaling pathways.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 256376-24-6
• MW: 360.39
• Purity: 99.86% (May vary between batches)
• Formula: C₂₀H₁₇FN₆
• SMILES: Nc1nc(ncc1C1CC1)-c1nn(Cc2ccccc2F)c2ncccc12
• Target: Guanylate cyclase
• Solubility: DMSO:36 mg/mL (99.89 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.77 mM)

Bioactivity

• In Vivo:
  In female spontaneously hypertensive rats, BAY 41-2272 (10 mg/kg, p.o.) shows antiplatelet effect, strongly decreases blood pressure and increases survival. In C. albicans-infected mice, BAY 41-2272 (10 mg/kg, i.p.) markedly increases macrophage-dependent cell influx to the peritoneum in addition to macrophage functions, and reduces the death rate. In db/db-/- type II diabetic and obese mice, BAY 41-2272 improves impaired corpus cavernosum (CC) relaxation.
• In Vitro:
  In vitro, BAY 41-2272 results in concentration dependent relaxation of human and rabbit cavernosum with EC50 of 489.1 nM and 406.3 nM, respectively.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BAY 41 2272, BAY 412272, BAY 41-2272, Guanylate cyclase, Guanylate Cyclase, Guanylatecyclase, Inhibitor, inhibit

Compound Identifiers

PubChem CID

9798973