BAY-293

SKU: orb1301805

Description

BAY-293

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2244904-70-7
• MW: 448.58
• Purity: 97.16%
• Formula: C₂₅H₂₈N₄O₂S
• SMILES: CNCc1ccccc1-c1csc(c1)[C@@H](C)Nc1nc(C)nc2cc(OC)c(OC)cc12
• Target: Ras,Raf
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.92 mM);DMSO:110 mg/mL (245.22 mM)

Bioactivity

• Target IC50:
  KRAS-SOS1:21 nM (cell free)
• In Vitro:
  BAY-293 is a SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 21 nM and displays no significant activity against KRAS WT-CRAF RBD, CDC42 and EGFR (>20 uM). It inhibits the activation of RAS in HeLa cells with IC50 of 410 nM, efficiently inhibits pERK levels in K562 cells after incubation for 60 min without affecting total protein levels of ERK (IC50: 180 nM). BAY-293 shows antiproliferative activity against wild-type KRAS cell lines (K562, MOLM-13; IC50~1 uM) and cell lines with KRASG12C mutation (NCI-H358, Calu-; IC50~3 uM) by preventing the formation of the KRAS-SOS1 complex.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, BAY293, BAY-293, BAY 293, SOS1, Ras

Compound Identifiers

PubChem CID

137322663