Bay 11-7085

SKU: orb1307063

Description

Bay 11-7085 is a cell-permeable inhibitor that potently and irreversibly blocks TNFα-induced IκBα phosphorylation with an IC50 of 10 µM. It is widely used in vitro and in vivo to study NF-κB signaling in inflammation, immunology, and cancer research.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 196309-76-9
• MW: 249.33
• Purity: 99.94% (May vary between batches)
• Formula: C₁₃H₁₅NO₂S
• SMILES: CC(C)(C)c1ccc(cc1)S(=O)(=O)\C=C\C#N
• Target: IκB/IKK,Ferroptosis,NF-κB,Apoptosis
• Solubility: DMSO:125 mg/mL (501.34 mM);Ethanol:24.9 mg/mL (99.87 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.02 mM)

Bioactivity

• Target IC50:
  IκBα phosphorylation:10 μM
• In Vivo:
  When used in conjunction with paclitaxel, BAY 11-7085 enhances the inhibition of NF-κB activity and reduces the survival rate of paclitaxel-treated cells. By inhibiting NF-κB, BAY 11-7085 suppresses the expression of the adhesion molecules E-selectin, ICAM-1, and VCAM-1 induced by TNFα. BAY 11-7085 (10 μM) exhibits no cytotoxicity towards HUVEC cells. Moreover, the combined use of BAY 11-7085 and LY294002 synergistically influences apoptosis in PEL cells.
• In Vitro:
  In athymic nude mice harboring Caov-3 cells, BAY 11-7085 enhances the inhibitory effect of paclitaxel on intraperitoneal spread and ascites formation. Additionally, BAY 11-7085 suppresses the increase in NF-κB activity associated with meningitis, improves the clinical condition of infected rats, and significantly reduces CNS complications and inflammation related to meningitis.
• Cell Research:
  Human umbilical vein endothelial cells (HUVEC) are isolated and maintained in culture. Cell toxicity is assessed by morphology and by MTT assay.(Only for Reference)

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, Bay 11 7085, BAY 11-7083, Bay 117085, BAY 11-7085, Bay 11-7085, inhibit, IκB, IκBα phosphorylation, NFkB, NF-kB, NFκB, NF-κB, Nuclear factor-κB, Nuclear factor-kappaB, Inhibitor, IKK, IkB/IKK, IkB, Ferroptosis

Compound Identifiers

PubChem CID

5353432