Bax activator-2

SKU: orb3210840

Description

Baxactivator-2 (compound 27c) is a pro-apoptotic agent targeting BAX, with an IC50 of 0.30 μmol/L for human BAX. It binds to BAX's trigger site, inducing a conformational change. Baxactivator-2 triggers mitochondrial depolarization, cytochrome c release, and caspase-3/9 and PARP cleavage, leading to apoptosis. It exhibits cytotoxicity across various cancer cell lines, with reduced cytotoxicity in BAX-knockout A549 cells and lower toxicity to non-cancer cell lines. This compound is applicable in research on acute myeloid leukemia and solid tumors.

Key Properties

• CAS Number: 3034297-25-8
• MW: 505.52
• Formula: C₃₀H₂₃N₃O₅
• SMILES: O=C(O)C1=CC=C(N1)C=2C=C(C=CC2OC=3C=CC(C=4C=CC=CC4)=C(C3)C)NC=5C=CC=CC5N(=O)=O
• Target: Bcl-2 Family

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Bcl-2 Family