Bavachinin

SKU: orb1222549

Description

Bavachinin(7-O-Methylbavachin) is a natural compound isolated from the Chinese herb Fructus Psoraleae with potent anti-angiogenic activity.

Key Properties

• CAS Number: 19879-30-2
• MW: 338.4
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₂O₄
• SMILES: [C@H]1(CC(=O)c2c(O1)cc(c(c2)CC=C(C)C)OC)c1ccc(cc1)O
• Target: Dehydrogenase
• Solubility: DMSO : ≥ 250 mg/mL; 738.77 mM

Bioactivity

• In Vivo:
  Animal model: Athymic nude mice inoculated subcutaneously KB cells. Dosage: 5 mg/kg. Administration: Intraperitoneal injection (i.p.). Result: Showed significantly reduced the tumor volume by 40.06%, and had fewer vessels of luminal size. Animal model: Asthma mice. Dosage: 50 mg/kg. Administration: Oral gavage (p.o.). Result: Showed significantly inhibiting the serum levels of both IL-4 and IgE.
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• In Vitro:
  Immunofluorescence Cell line: A549 cells. Concentration: 25 μM, 50 μM. Incubation time: 24 h. Result: Showed PPARγ protein levels in both the cytoplasm and the nucleus were markedly higher.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

7-O-Methylbavachin | Bavachinin A

Quick Database Links

Gene Symbol

Dehydrogenase