Batefenterol

SKU: orb1224092

Description

A bifunctional M3 mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi/pEC50 of 8.7/9.6 for hM3/hβ2 respectively; shows weak effect on β1; the first MABA compound to enter clinical trials and demonstrate proof of concept and efficacy in COPD.COPD Phase 2 Clinical.

Key Properties

• CAS Number: 743461-65-6
• MW: 740.2438
• Purity: >98% (HPLC)
• Formula: C₄₀H₄₂ClN₅O₇
• SMILES: O=C(OC1CCNCC1)NC2=CC=CC=C2(CCC(NC3=CC(OC)=C(CNC[C@H](O)C4=CC=C(O)C5=C4C=CC(N5)=O)C=C3Cl)=O)C6=CC=CC=C6
• Target: mAChR
• Solubility: DMSO: 10 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK961081 | TD-5959

Quick Database Links

Gene Symbol

mAChR