Batatasin III

SKU: orb1297447

Description

Batatasin III is a bioactive small molecule that suppresses cancer cell migration and invasion by inhibiting epithelial-mesenchymal transition (EMT) and the FAK/AKT signaling pathway. It has demonstrated anti-cancer activity in vitro and also exhibits plant growth inhibitory effects, including the suppression of germination.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 56684-87-8
• MW: 244.29
• Purity: 99.16% (May vary between batches)
• Formula: C₁₅H₁₆O₃
• SMILES: COc1cc(O)cc(CCc2cccc(O)c2)c1
• Target: FAK,Akt

Bioactivity

• In Vivo:
  Batatasin III may impose a lethal effect on the aquatic fauna in small streams. The maximum concentration of Batatasin III found was 1.06 mg l(-1). The proportion of dead yolk sac alevins increased significantly (P < 0.001) with increasing concentrations of Batatasin III and time of exposure. After 24 hr, EC50 was 10 mg l(-1). It was 2 mg l(-1) after 48 hr. The effect of phenol was negligible, indicating a specific phytotoxic effect of the bibenzyl structure of Batatasin III. The proportion of mobile D. magna became significantly smaller (P < 0.001) with increasing concentrations of Batatasin III, with decreasing pH, and with increasing exposure time. EC50 varied between 7 and 17 mg l(-1) at pH 5.5 and 7.0, respectively. After 24 hr EC50 decreased and was 2.5 at pH 5.5 and 12 mg l(-1) at pH 7.0. The levels of Batatasin III found in the field samples were below the lowest EC50 in acute toxicity tests. Batatasin III significantly suppresses mesenchymal transition indicated by the decrease of N-cadherin and Vimentin and up-regulation of E-cadherin. Batatasin III (25-100 μM; 48 h) exhibits anti-proliferative activity in H460 cells. Batatasin III at concentrations lower than 100 μM has no cytotoxic effects.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, FAK, Focal adhesion kinase, AKT1-FAK, Batatasin III, Akt, PTK2, PTK2 protein tyrosine kinase 2, Protein kinase B, PKB

Compound Identifiers

PubChem CID

10466989