Barnidipine hydrochloride

SKU: orb1301427

Description

Barnidipine hydrochloride

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 104757-53-1
• MW: 528
• Purity: 99.88% (May vary between batches)
• Formula: C₂₇H₃₀ClN₃O₆
• SMILES: Cl.COC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)O[C@H]1CCN(Cc2ccccc2)C1
• Target: Calcium Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.47 mM);DMSO:250 mg/mL (473.48 mM)

Bioactivity

• Target IC50:
  [3H]-Initrendipine:0.21 nmol/l (Ki)
• In Vivo:
  Barnidipine demonstrates antihypertensive activity by reducing peripheral vascular resistance. It decreases blood pressure in spontaneously hypertensive rats when administered orally at 1 and 3 mg/kg per day. Formulations containing barnidipine have been used as a treatment for hypertension. In obstructive sleep apnea patients with non-dipper pattern hypertension, barnidipine reduced mean nighttime systolic and diastolic arterial blood pressure.
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• Animal Research:
  Forty-one patients (mean age 69 ± 17 years, 18 females) with previously diagnosed OSA (by reduced channel home-based polysomnography) who were not being treated with continuous positive airway pressure (CPAP) because of contraindications or because of patient intolerance or rejection were evaluated. Non-dipper status was defined as the presence of a nighttime fall in systolic blood pressure (BP) which was < 10% that of daytime systolic BP as observed in a previous ambulatory blood pressure (ABP) monitoring. OSA was defined according to the presence of 5 or more episodes per hour of apnoea, hypopnoea or arousal due to respiratory effort. The reproducibility of non-dipping status was confirmed through a second 24-h ABP monitoring performed at baseline. On top of the previous stable treatment regimen (which excluded calcium-channel blockers), a 10 mg dosing of barnidipine hydrochloride at bedtime was added to all subjects during a 12-week period.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Mepirodipine, Mepirodipine (hydrochloride), Calcium Channel, Ca channels, Ca2+ channels, Barnidipine, Barnidipine hydrochloride, Barnidipine Hydrochloride, CalciumChannel, YM-09730-5 hydrochloride, YM-09730-5 Hydrochloride

Compound Identifiers

PubChem CID

45356886