BAMB-4

SKU: orb1219501

Description

Bamb-4 is a highly membrane-permeable inhibitor of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA). It acts by suppressing the metastasis-promoting effect of ITPKA in lung tumor cells(with IC50 of 37 μM in ADP-Glo Assay).

Key Properties

• CAS Number: 891025-25-5
• MW: 252.27
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₂N₂O₂
• SMILES: Cc1ccc(cc1)C(=O)Nc1noc2ccccc12
• Target: ITPKA
• Solubility: DMSO:39 mg/mL(154.6 mM)

Bioactivity

• In Vitro:
  BAMB-4 (0.3-40 μM) has ITPKA inhibiton effect with an IC50 value of 37 μM. BAMB-4 (40 μM) inhibits InsP3 kinase activity with an IC50 value of 20 μM. BAMB-4 (100 μM, overnight) has high specificity and the high cellular uptake. BAMP-4 (0, 10, 20 and 40 μM) shows increased Km and decreased V max. BAMP-4 (0-30 μM) is a mixed type inhibitor with respect to ATP and InsP3 and does notonly affect binding of ATP but also binding of InsP3, which affects turnover of two substrate exhibit a higher inhibition specifcity.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ITPKA-IN-C14

Quick Database Links

Gene Symbol

ITPKA