Baicalin methyl ester

SKU: orb1297450

Description

Baicalin methyl ester is a bioactive flavonoid derivative that acts as an inhibitor of Avian Myeloblastosis Virus Reverse Transcriptase (AMV-RT). This compound is a valuable research tool for studying retroviral enzyme mechanisms in vitro and exploring potential antiviral strategies.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 82475-03-4
• MW: 460.39
• Purity: 99.44% (May vary between batches)
• Formula: C₂₂H₂₀O₁₁
• SMILES: COC(=O)[C@H]1O[C@@H](Oc2cc3oc(cc(=O)c3c(O)c2O)-c2ccccc2)[C@H](O)[C@@H](O)[C@@H]1O
• Target: Anti-infection
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.34 mM);DMSO:45 mg/mL (97.74 mM)

Bioactivity

• In Vitro:
  One hundred-ninety flavonoids and 75 alkaloids were studied for their inhibitory effects on the Avian Myeloblastosis Virus reverse transcriptase (AMV-RT) by using (rA) n-p(dT) <12-18> or (rC) n-p(dG) <12-18> as a template-primer. Of the flavonoids tested, 6-hydroxyluteolin (50), pedalitin (52), 6-hydroxykaempferol (109) and quercetagetin (129), were the most potent inhibitors with IC50 :10 μM. Five other flavonoids, baicalein (19), Baicalin methyl ester (23), scutellarein (33), myricetin (126) and gossypetin (130), gave IC50 between 35 and 200 μM. The kinetic studies on 50, 126 and 130 gave the inhibitory constants ki of 10, 94 and 90 μM, respectively, with respect to the substrate and 5, 200 and 100 μM, respectively, with respect to the template-primer. Structurally different alkaloids such as isoquinoline, indol, steroidal, quinolizidine, pyrrolizidine, pyridine and imidazole alkaloids were also investigated for the activity and berberine type alkaloids were shown to have a strong inhibitory activity.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Anti-infection, Antiinfection, Antifection, Baicalin methyl ester

Compound Identifiers

PubChem CID

15223582