BAI1

SKU: orb1301995

Description

BAI1 is a potent small molecule Bax channel blocker that inhibits Bax-induced cytochrome c release from mitochondria with an IC50 of 0.52 µM. It is a valuable research tool for studying apoptosis mechanisms in cellular models and has been used in vitro to investigate cardioprotection and neuroprotection.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 335165-68-9
• MW: 467.2
• Purity: ＞99.99% (May vary between batches)
• Formula: C₁₉H₂₁Br₂N₃O
• SMILES: OC(CN1CCNCC1)Cn1c2ccc(Br)cc2c2cc(Br)ccc12
• Target: Bcl-2 Family,Apoptosis
• Solubility: H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.14 mM);DMSO:9.52 mg/mL (20.38 mM)

Bioactivity

• Target IC50:
  Bax:0.52 μM
• In Vitro:
  V-9302 inhibited ASCT2-mediated glutamine uptake in human cells in a concentration-dependent fashion and exhibited a 100-fold improvement in potency (IC50 V-9302 = 9.6 μM) over gamma-L-glutamyl-p-nitroanilide (GPNA; IC50 = 1000 μM). The EC50 concentration
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

pathway, mitochondrial, Inhibitor, inhibit, effector, death, Apoptosis, BAX, Bax, BAI 1, BAI1, BAI-1, Bcl-2 Family, cell, critical

Compound Identifiers

PubChem CID

2729027