BAG3/HSP70-IN-1

• Catalog Number: orb2944600
• Category: Small Molecules
• Description: USP1-IN-11 (compound 38-P2) is a selective, reversible, and non-competitive inhibitor of USP1 (Ubiquitin-specific protease 1). It activates the DDR (DNA damage repair) pathway, leading to cell cycle arrest and apoptosis, thereby inhibiting cell survival. USP1-IN-11 increases sensitivity to Olaparib in drug-resistant cells and works synergistically with Andrographolide in cancer cells with functional BRCA. In the MDA-MB-436 xenograft model, USP1-IN-11 demonstrates significant dose-dependent antitumor activity.
• Target: Caspase,Apoptosis,HSP
• MW: 537.65
• Formula: C₂₈H₃₉N₇O₄
• Storage: -20°C
• Research Area: Cell Biology, Metabolism Research, Protein Biochem
• Note: For research use only
• Expiration Date: 12 months from date of receipt.