BAG3/HSP70-IN-1

SKU: orb2944600

Description

USP1-IN-11 (compound 38-P2) is a selective, reversible, and non-competitive inhibitor of USP1 (Ubiquitin-specific protease 1). It activates the DDR (DNA damage repair) pathway, leading to cell cycle arrest and apoptosis, thereby inhibiting cell survival. USP1-IN-11 increases sensitivity to Olaparib in drug-resistant cells and works synergistically with Andrographolide in cancer cells with functional BRCA. In the MDA-MB-436 xenograft model, USP1-IN-11 demonstrates significant dose-dependent antitumor activity.

Research Area

Cell Biology, Metabolism Research, Protein Biochemistry, Signal Transduction

Key Properties

• MW: 537.65
• Formula: C₂₈H₃₉N₇O₄
• Target: Caspase,Apoptosis,HSP

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Caspase,Apoptosis,HSP