Bacoside A3

SKU: orb1297451

Description

Bacoside A3 is a bioactive constituent of Bacopa monnieri's bacoside A complex, recognized for its antioxidant properties. It demonstrates significant neuroprotective effects in vitro, evidenced by enhanced neuronal cell viability and reduced intracellular reactive oxygen species (ROS). This compound is utilized in neuroscience research exploring oxidative stress and neuroprotection.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 157408-08-7
• MW: 929.10
• Purity: 99.86% (May vary between batches)
• Formula: C₄₇H₇₆O₁₈
• SMILES: [H][C@@]1(O[C@@H]2[C@@H](O[C@]3([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@@H](CO)O[C@@]2([H])O[C@H]2CC[C@@]3(C)[C@@]([H])(CC[C@]4(C)[C@]3([H])CC[C@]3([H])[C@]5([H])[C@]6(C[C@@]43CO6)O[C@H](C[C@]5(C)O)C=C(C)C)C2(C)C)O[C@@H](CO)[C@H](O)[C@H]1O
• Target: Apoptosis,ROS,NO Synthase,ATPase,COX,P-gp
• Solubility: DMSO:60.00 mg/mL (64.58 mM)

Bioactivity

• In Vitro:
  The cytoprotective effects of individual bacoside A components were evaluated towards oxidative stressed neuronal cells. Bacoside A was screened for neuronal cell viability (MTT assay) and change in intracellular reactive oxygen species (ROS), anti-apoptotic properties and mitochondrial membrane potential (MMP) using fluorescence microscopy. Different bacoside A components showed decrease in N2a cell viability below 100 (%) after bacoside A concentration of 0.4 mg/ml. Further, cytoprotective effect of optimized dose of bacoside A was analysed for alleviating oxidative stressed, apoptosis and MMP in H2 O2 stressed neuronal cells. Results showed increase in MMP, and decrease in apoptotic induction, without much change in nuclear integrity in stressed neuronal cells. Results showed Bacoside A3 and bacopaside II have comparatively higher cytoprotective ability whilst isomer of bacopasponin C, bacopasaponin C and mixture showed comparatively less response
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bacoside A 3, Bacoside A3, Bacoside A-3, ATPase, Inhibitor, inhibit, ROS, P-gp, Pgp

Compound Identifiers

PubChem CID

91827005