BACE1/2-IN-1

SKU: orb1688082

Description

BACE1/2-IN-1 (compound 34) is a potent dual inhibitor of BACE1 and BACE2 enzymes, exhibiting IC50 values of 0.01 and 0.0053 μM, respectively. It features a favorable pharmacokinetic profile with reduced Pgp efflux and enhanced permeability, though it shows decreased metabolic stability in liver microsomes. This inhibitor is a valuable research tool for in vitro and in vivo studies investigating Alzheimer's disease and type 2 diabetes.

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 2671036-34-1
• MW: 401.57
• Formula: C₂₁H₃₁N₅OS
• SMILES: C(OC[C@H]1[C@H](C)C1)(C)(C)[C@H]2[C@]([C@@]34[C@@](CN(C3)C=5N=CC=CN5)(CSC(N)=N4)[H])(C2)[H]
• Target: Others,Beta-Secretase,Beta Amyloid

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

145704720