BACE1-IN-5

SKU: orb1710331

Description

BACE1-IN-5 (Compound 15) is a potent small molecule inhibitor of BACE1, exhibiting an IC50 of 9.1 nM against the enzyme and 0.82 nM in cellular Aβ reduction assays. Its optimized profile includes considerations for hERG and P-gp, making it a valuable chemical probe for Alzheimer's disease research in both biochemical and cell-based studies.

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 2581114-83-0
• MW: 461.41
• Formula: C₁₈H₁₆F₅N₅O₂S
• SMILES: C[C@]1(C[C@@H](C(F)(F)F)SC(N)=N1)C2=CC(NC(=O)C=3C=NC(OCF)=CN3)=CC=C2F
• Target: BACE,Beta-Secretase,Beta Amyloid

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

139600334