BACE1-IN-13

SKU: orb2278235

Description

BACE1-IN-13 (Compound 36) is a potent, orally bioavailable BACE1 inhibitor with IC50 values of 2.9 nM and 1.3 nM in biochemical and cellular (hAβ42) assays, respectively. It demonstrates a sustained reduction of Aβ42 in vivo in mouse and dog models and shows a favorable cardiovascular safety profile, supporting its use in Alzheimer's disease research.

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 1397683-26-9
• MW: 420.4
• Formula: C₂₀H₁₇FN₈O₂
• SMILES: C[C@]1(CN2C(C(N)=N1)=CC(C#N)=N2)C3=CC(NC(=O)C=4C=NC(OC)=CN4)=CC=C3F
• Target: Beta-Secretase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

140629025