B2

SKU: orb1305874

Description

This small molecule, known as B2 or Linazolamide intermediate B impurity 2, has been shown to induce protein aggregation in cellular models of Huntington's and Parkinson's disease. It serves as a research tool for studying neurodegenerative disease mechanisms in vitro, particularly related to pathological inclusion formation.

Research Area

Epigenetics & Chromatin, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 115687-05-3
• MW: 396.83
• Purity: 99.66%
• Formula: C₂₀H₁₇ClN₄O₃
• SMILES: [O-][N+](=O)c1ccc(N2CCN(CC2)C(=O)c2ccc(Cl)cc2)c2cccnc12
• Target: Sirtuin,HIF/HIF Prolyl-Hydroxylase
• Solubility: H2O:2 mg/mL (5.04 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:50 mg/mL (126 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sirtuin, 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline, B2, B-2, B 2, CPNQ, Huntington's diseases, HIF/HIFProlylHydroxylase, HIF/HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF ProlylHydroxylase, HIF, Inhibitor, HIFProlylHydroxylase, Linazolamide intermediate B impurity 2, inhibit, Parkinson's diseases

Compound Identifiers

PubChem CID

3953303