B022

SKU: orb1707598

Description

B022 is a potent and selective NIK inhibitor (Ki = 4.2 nM) used as a chemical probe to study NF-κB signaling. It has demonstrated protective effects against oxidative stress and toxin-induced liver inflammation and injury in preclinical in vivo models, supporting research in hepatology and inflammation.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1202764-53-1
• MW: 397.88
• Purity: 99.74% (May vary between batches)
• Formula: C₁₉H₁₆ClN₅OS
• SMILES: CC(O)(C#Cc1ccc2CCN(c2c1)c1nc(N)ncc1Cl)c1nccs1
• Target: NF-κB
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (12.57 mM);DMSO:200 mg/mL (502.66 mM)

Bioactivity

• Target IC50:
  NF-κB-inducing kinase (NIK):4.2 nM (Ki)
• In Vivo:
  In STOP-NIK male mice (8 weeks old) infected with Ad-cre, B022 (30 mg/kg; intravenous injection; twice daily; for 10 days) completely prevents the lethal effects induced by abnormally high levels of hepatic NIK in mice. It inhibits the majority of the deteriorating effects caused by aberrant activation of hepatic NIK.
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• In Vitro:
  B022 treatment of Hepa1 cells (0 μM, 0.5 μM, 5 μM; 12 hours) can suppress NIK-induced p52 formation in a dose-dependent manner.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

B022, B-022, B 022, NIK, NF-κB-inducing kinase NIK, NFκB, NF-kB, NFkB

Compound Identifiers

PubChem CID

58221879