B-Raf IN 11

SKU: orb1306868

Description

B-Raf IN 11 is a novel, selective inhibitor that preferentially targets the DFG-in conformation of the B-Raf V600E mutant kinase. This compound is a valuable research tool for investigating colorectal cancer mechanisms and evaluating therapeutic strategies in both cellular and animal models of the disease.

Research Area

Signal Transduction

Key Properties

• CAS Number: 918504-27-5
• MW: 458.28
• Purity: 99.46% (May vary between batches)
• Formula: C₁₇H₁₄BrF₂N₃O₃S
• SMILES: C(=O)(C=1C=2C(NC1)=NC=C(Br)C2)C3=C(F)C(NS(CCC)(=O)=O)=CC=C3F
• Target: Raf
• Solubility: DMSO:60 mg/mL (130.92 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.36 mM)

Bioactivity

• Target IC50:
  B-Raf (WT):238 nM|B-Raf (V600E):76 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

B-Raf (V600E), B-Raf IN 11, ZINC72115182, ZINC-72115182

Compound Identifiers

PubChem CID

11984556