Azvudine hydrochloride

SKU: orb1691815

Description

Azvudine hydrochloride is a potent, orally bioavailable nucleoside reverse transcriptase inhibitor (NRTI) with broad-spectrum antiviral activity against HIV, HBV, and HCV. It functions by inhibiting viral RNA-dependent RNA polymerase (RdRp), making it a compound of interest for research into COVID-19, with applications in both in vitro and in vivo antiviral studies.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 1333126-31-0
• MW: 322.68
• Purity: 99.06% (May vary between batches)
• Formula: C₉H₁₂ClFN₆O₄
• SMILES: Cl.Nc1ccn([C@@H]2O[C@@](CO)(N=[N+]=[N-])[C@@H](O)[C@@H]2F)c(=O)n1
• Target: Antiviral,HBV,HIV Protease,Reverse Transcriptase,HCV Protease
• Solubility: DMSO:100 mg/mL (309.9 mM)

Bioactivity

• Target IC50:
  HIV-2:0.018-0.02 nM (EC50)|HIV-1:0.03-6.92 nM (EC50)
• In Vitro:
  Azvudine hydrochloride exhibits potent inhibitory effects against HIV-1 (EC50 = 0.03-6.92 nM) and HIV-2 (EC50 = 0.018-0.025 nM). When used in combination with six approved anti-HIV drugs in C8166 and PBMC cells, it also demonstrates synergistic effects.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RO 0622 Hydrochloride, RO0622 Hydrochloride, RO-0622 hydrochloride, antiviral, FNC hydrochloride, FNChydrochloride, HCVProtease, HCV, HCV Protease, HBV, HIV, HIV Protease, HIVProtease

Compound Identifiers

PubChem CID

54579399