Azumolene

SKU: orb1298613

Description

Azumolene (EU4093 free base)

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 64748-79-4
• MW: 349.14
• Purity: 98.59%
• Formula: C₁₃H₉BrN₄O₃
• SMILES: Brc1ccc(cc1)-c1cnc(\C=N\N2CC(=O)NC2=O)o1
• Target: Calcium Channel
• Solubility: 10% DMSO+90% Saline:1.5 mg/mL (4.3 mM);DMSO:45 mg/mL (128.89 mM)

Bioactivity

• In Vivo:
  Azumolene is a Direct acting, skeletal musclee relaxant with structural similarities to dantrolene sodium in tha the para-nitro phenyl group of dantrolene sodium is replaced by a para-bromo phenyl group.2.The effect of Azumolene o the twitch o the intact rat soleus preparation is nearly maximal at a dose of 20 mg kg-1.This dose of Azumolene reduce the amplitude o the twitch to 31.9% o the control value.By comparison, dantrolene sodium reduce the twitch amplitude to 31.3% o the control value at a dose of 5 mg kg-1.3.The contraction of intrafusal musclee as measured b the response of spindle afferent discharge was also reduced by Azumolene.4.The most significant difference betwee the effect of Azumolene and dantrolene sodium o the contraction of intrafusal musclee was that Azumolene had an appreciable depressant action at high stimulation frequencies at which dantrolene sodium had only a minimal relaxant effect o the intrafusal musclee contraction.

Storage & Handling

• Storage: keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Ca channels, Calcium Channel, CalciumChannel, Ca2+ channels, calcium, Azumolene, inhibit, muscle, Inhibitor, EU4093, EU-4093, EU4093 free base, EU 4093, SOCE, ryanodine, relaxant, receptor

Compound Identifiers

PubChem CID

9568620