Azumolene

SKU: orb1298613

Description

Azumolene (EU4093 free base) is a ryanodine receptor antagonist used in research. It is applied in studies of malignant hyperthermia and muscle physiology, serving as a research tool in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 64748-79-4
• MW: 349.14
• Purity: 98.59% (May vary between batches)
• Formula: C₁₃H₉BrN₄O₃
• SMILES: Brc1ccc(cc1)-c1cnc(\C=N\N2CC(=O)NC2=O)o1
• Target: Calcium Channel
• Solubility: 10% DMSO+90% Saline:1.5 mg/mL (4.3 mM);DMSO:45 mg/mL (128.89 mM)

Bioactivity

• In Vivo:
  Azumolene is a direct acting, skeletal muscle relaxant with structural similarities to dantrolene sodium in that the para-nitro phenyl group of dantrolene sodium is replaced by a para-bromo phenyl group.2.The effect of Azumolene on the twitch of the intact rat soleus preparation is nearly maximal at a dose of 20 mg kg-1.This dose of Azumolene reduces the amplitude of the twitch to 31.9% of the control value.By comparison, dantrolene sodium reduced the twitch amplitude to 31.3% of the control value at a dose of 5 mg kg-1.3.The contraction of intrafusal muscle as measured by the response of spindle afferent discharge was also reduced by Azumolene.4.The most significant difference between the effect of Azumolene and dantrolene sodium on the contraction of intrafusal muscle was that Azumolene had an appreciable depressant action at high stimulation frequencies at which dantrolene sodium had only a minimal relaxant effect on the intrafusal muscle contraction.

Storage & Handling

• Storage: keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ca channels, Calcium Channel, CalciumChannel, Ca2+ channels, calcium, Azumolene, inhibit, muscle, Inhibitor, EU4093, EU-4093, EU4093 free base, EU 4093, SOCE, ryanodine, relaxant, receptor

Compound Identifiers

PubChem CID

9568620