AZM475271

SKU: orb1707601

Description

AZM475271 is a highly potent and selective Src kinase inhibitor with an IC50 of 5 nM. This compound is a valuable research tool for investigating Src-related signaling pathways in cancer and bone metabolism, applicable in both cellular and animal model studies.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 476159-98-5
• MW: 442.94
• Purity: 99.78%
• Formula: C₂₃H₂₇ClN₄O₃
• SMILES: COc1ccc(Cl)c(Nc2ncnc3cc(OCC4CCN(C)CC4)c(OC)cc23)c1
• Target: Others,Src,Apoptosis
• Solubility: DMSO:42 mg/mL (94.82 mM)

Bioactivity

• In Vivo:
  Treatment with gemcitabine or AZM475271 alone did not significantly change animal weight . In vivo: Tumors appeared to be palpable at day 14 after tumor cell injection in all animals except mice treated with both AZM475271 and gemcitabine, in which the earliest possible palpation of the tumors was at day 17 after tumor cell injection.
• In Vitro:
  AZM475271 demonstrated strong dose-dependent inhibition of Src tyrosine kinase activity in the L3.6pl human pancreatic carcinoma cell line. The IC50 concentration of AZM475271 to inhibit the phosphorylation of c-src, lck, and c-yes was 0.01, 0.03, and 0.08 μmol/L, respectively, in comparison with an IC50 of 0.7 μmol/L AZM475271 to inhibit KDR . Maximum reduction of Src kinase activity was observed after incubation for 4 hours with ≥5 μmol/L.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AZM 475271, AZM475271, AZM-475271, M 475271, M475271, M-475271

Compound Identifiers

PubChem CID

5330175