Azido-PEG2-azide

SKU: orb1307541

Description

Azido-PEG2-azide is a bifunctional polyethylene glycol linker utilized in constructing PROTAC molecules for targeted protein degradation. This reagent is applicable in both in vitro biochemical assays and in vivo research to develop novel therapeutic strategies against diseases like cancer.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 59559-06-7
• MW: 200.2
• Purity: >99.99% (May vary between batches)
• Formula: C₆H₁₂N₆O₂
• SMILES: [N-]=[N+]=NCCCOCOCCN=[N+]=[N-]
• Target: PROTAC Linker
• Solubility: DMSO:100 mg/mL (499.5 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (19.98 mM)

Bioactivity

• In Vitro:
  PROTACs consist of two distinct ligands joined by a linker: one targets an E3 ubiquitin ligase, and the other targets the specific protein. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Azido PEG2 azide, AzidoPEG2azide, Azido-PEG-2-azide, Azido-PEG2-azide, inhibit, Inhibitor, PROTAC Linkers, PROTAC Linker, PROTACLinker, PEGs

Compound Identifiers

PubChem CID

53407177