AZD8421

SKU: orb2695185

Description

AZD8421 is a potent and highly selective inhibitor of cyclin-dependent kinase 2 (CDK2) with an IC50 of 9nM, demonstrating greater selectivity over CDK1, CDK4, and CDK6. This compound also exhibits antiproliferative properties by effectively inhibiting Rb phosphorylation. In models of breast and ovarian cancer, AZD8421 has shown significant activity both as a monotherapy and in combination with CDK4/6 inhibitors.

Key Properties

• CAS Number: 3047321-53-6
• MW: 440.56
• Formula: C₁₈H₃₂N₈O₃S
• SMILES: N(C1=C2C(N(CC)C=N2)=NC(N[C@H]([C@@H](C)O)CC)=N1)[C@@H]3CN(S(NCC)(=O)=O)CC3

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only