AZD5582

SKU: orb1707609

Description

AZD5582

Research Area

Cell Biology

Key Properties

• CAS Number: 1258392-53-8
• MW: 1015.29
• Purity: 98.75% (May vary between batches)
• Formula: C₅₈H₇₈N₈O₈
• SMILES: OC(=O)C(F)(F)F.CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H]1[C@@H](Cc2ccccc12)OCC#CC#CCO[C@@H]1Cc2ccccc2[C@@H]1NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C1CCCCC1
• Target: Apoptosis,IAP
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (1.97 mM);DMSO:66.25 mg/mL (65.25 mM)

Bioactivity

• Target IC50:
  CIAP1:15 nM (IC50)|CIAP2:21 nM (IC50)|XIAP:15 nM (IC50)
• In Vivo:
  AZD5582 (intravenous injection; 0.1-3.0 mg/kg; once a week; 2 weeks) induces cIAP1 degradation and caspase 3 cleavage in tumor cells, leading to significant tumor resolution after two weeks. A medium dose (0.5 mg/kg) of AZD5582 degrades cIAP1 but requires additional time to achieve apoptosis-inducing effects.
• In Vitro:
  AZD5582 (20 nM; 48 hours) inhibited cell viability by cooperating with IFNγ or viral double-stranded RNA (dsRNA) in H1975 NSCLC cells. In HCC827 NSCLC cells, AZD5582 (20 nM; 48 hours) induced apoptosis by activating cell death and caspase-3/-8 through co-treatment with IFNγ. Additionally, AZD5582 (20 nM; 17 or 25 hours) down-regulated cIAP-1, activated RIPK1 (an upstream regulator of caspase-8), and initiated both extrinsic (caspase-8) and intrinsic (caspase-9) apoptosis pathways, leading to the cleavage of caspase-3 and caspase-7.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cIAP2-BIR3, cIAP1, Apoptosis, AZD5582, AZD-5582, AZD 5582, Inhibitor, IAP, inhibit, XIAP

Compound Identifiers

PubChem CID

171360478