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AZD5305

SKU: orb1218263

Description

AZD5305 is a potent, selective and oral active PARP inhibitor.

Images & Validation

Key Properties

CAS Number2589531-76-8
MW406.48
Purity>98% (HPLC)
FormulaC22H26N6O2
SMILESO=C(C1=NC=C(N2CCN(CC3=CC(N4)=C(N=C3)C=C(CC)C4=O)CC2)C=C1)NC
TargetPARP
SolubilityDMSO:41.67 mg/mL (102.51 mM; Need ultrasonic)

Bioactivity

In Vivo
Animal model: Female Han Wistar rats with BRCAm xenograft and PDX models (12-13 weeks of age). Dosage: 0.01, 0.03, 0.1, and 0.3 mg/kg. Administration: Oral administration; daily, for 35 days. Result: Had antitumor efficacy in a dose-dependent manner.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

Available Sizes

Select a size below

200 mg
500 mg
5 mg
$ 400.00
10 mg
$ 630.00
25 mg
$ 1,030.00
50 mg
$ 1,460.00
100 mg
$ 1,970.00