AZD4747

SKU: orb1944304

Description

AZD4747 is a brain-penetrant, selective inhibitor of the KRASG12C mutant protein. It is utilized in preclinical oncology research, particularly for studying pancreatic and colorectal cancers, with demonstrated activity in both cellular assays and in vivo tumor models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2489226-14-2
• MW: 440.89
• Purity: 99.36% (May vary between batches)
• Formula: C₂₄H₂₂ClFN₂O₃
• SMILES: O=C(C=C)N1CCN2CC3=CC(C#CC)=C(C(F)=C3OCC2C1)C=4C(Cl)=CC=CC4O
• Target: Ras,Kras
• Solubility: DMSO:100 mg/mL (226.81 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KRAS G12C

Compound Identifiers

PubChem CID

170420906