AZD4635

SKU: orb1303008

Description

AZD4635 (HTL1071) is a potent and selective adenosine A2A receptor antagonist with a Ki of 1.7 nM. It is a valuable research tool for investigating adenosine signaling in immuno-oncology, with demonstrated activity in both in vitro cellular assays and in vivo tumor models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1321514-06-0
• MW: 315.73
• Purity: 99.90% (May vary between batches)
• Formula: C₁₅H₁₁ClFN₅
• SMILES: Cc1cc(cc(Cl)n1)-c1nnc(N)nc1-c1ccc(F)cc1
• Target: Adenosine Receptor
• Solubility: H2O:< 0.1 mg/mL (insoluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.45 mM);DMSO:83.3 mg/mL (263.83 mM)

Bioactivity

• Target IC50:
  A2A receptor:Ki: 1.7 nM

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

P1 receptor, AdenosineReceptor, Adenosine Receptor, A2A, AZD 4635, AZD4635, AZD-4635, inhibit, Imaradenant, HTL 1071, HTL1071, HTL-1071, Inhibitor

Compound Identifiers

PubChem CID

86676119