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AZD4625

SKU: orb1818626

Description

AZD4625 is a potent, selective, covalent allosteric inhibitor of mutant GTPase KRAS G12C with IC50 of 3 nM, inhibitor H358 cell proliferation with GI50 of 4 nM.AZD4625 is a clinical development candidate for the treatment of KRASG12C positive tumors.

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Key Properties

MW486.904
FormulaC24H21ClF2N4O3
SMILESC=CC(N1C[C@H]2N(C3=C4C(OCC2)=C(Cl)[C@@]([C@@]5=C(F)C=CC=C5O)=C(F)C4=NC=N3)C[C@H]1C)=O

Storage & Handling

DisclaimerFor research use only

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    C24H21ClF2N4O3

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Protocol Information

AZD4625 (orb1818626)

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5 mg
$ 2,060.00
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