AZD4144

SKU: orb2646011

Description

AZD4144 is a potent, selective NLRP3 inflammasome inhibitor (IC50 = 54 nM) that competitively displaces MCC950. It effectively reduces IL-1β and IL-18 release in cellular assays and is a valuable research tool for studying NLRP3-driven pathologies like inflammatory and autoimmune diseases in both in vitro and in vivo models.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 2890191-41-8
• MW: 379.33
• Purity: 99.02%
• Formula: C₁₈H₁₆F₃N₃O₃
• SMILES: OC1=C(C=2C3=C(C(NC[C@@H](CO)O)=NN2)C=CC=C3)C=CC(C(F)(F)F)=C1
• Target: NOD
• Solubility: DMSO:100 mg/mL (263.62 mM)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166456099